Targeting Misfolded Proteins to Fight Neurodegenerative Diseases
نویسندگان
چکیده
منابع مشابه
Targeting Misfolded Proteins to Fight Neurodegenerative Diseases
With the assistance of proteins called chaperones, newly translated proteins fold into the three-dimensional shapes that are critical to their function. When proteins fold abnormally or become unstable, the consequences can be dire for cells, particularly neurons, which are exquisitely sensitive to the accumulation of misfolded proteins. Many neurodegenerative diseases, like Parkinson’s and Cre...
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Inam Neuroscience Research Center, Department of Neurology, Sanbon Medical Center, Wonkwang University College of Medicine, Gunpo; Department of Neurology*, Seoul National University College of Medicine & Seoul National University Bundang Hospital, Seoul, Korea During recent years, there has been remarkable progress with respect to the identification of molecular mechanisms and underlying patho...
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Protein misfolding is a common event in living cells. Molecular chaperones not only assist protein folding; they also facilitate the degradation of misfolded polypeptides. When the intracellular degradative capacity is exceeded, juxtanuclear aggresomes are formed to sequester misfolded proteins. Despite the well-established role of chaperones in both protein folding and degradation, how chapero...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2010
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1000290